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Ajaib S Paintlia Selected Research

Lovastatin (Mevacor)

9/2013Modulation of Rho-Rock signaling pathway protects oligodendrocytes against cytokine toxicity via PPAR-α-dependent mechanism.
6/2013Combinatorial Effect of Metformin and Lovastatin Impedes T-cell Autoimmunity and Neurodegeneration in Experimental Autoimmune Encephalomyelitis.
11/2010Activation of PPAR-γ and PTEN cascade participates in lovastatin-mediated accelerated differentiation of oligodendrocyte progenitor cells.
1/2009Combination therapy of lovastatin and rolipram provides neuroprotection and promotes neurorepair in inflammatory demyelination model of multiple sclerosis.
12/2008Combined medication of lovastatin with rolipram suppresses severity of experimental autoimmune encephalomyelitis.
9/2006Immunomodulatory effect of combination therapy with lovastatin and 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside alleviates neurodegeneration in experimental autoimmune encephalomyelitis.
9/2005HMG-CoA reductase inhibitor augments survival and differentiation of oligodendrocyte progenitors in animal model of multiple sclerosis.
10/2004Impaired peroxisomal function in the central nervous system with inflammatory disease of experimental autoimmune encephalomyelitis animals and protection by lovastatin treatment.

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Ajaib S Paintlia Research Topics

Disease

11Demyelinating Diseases (Demyelinating Disease)
08/2013 - 10/2004
9Multiple Sclerosis
09/2013 - 09/2005
8Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental)
08/2013 - 10/2004
4Inflammation (Inflammations)
08/2013 - 09/2006
3Neurodegenerative Diseases (Neurodegenerative Disease)
09/2013 - 09/2012
2Infections
10/2008 - 05/2008
2Neuroinflammatory Diseases
04/2006 - 09/2005
1Neurologic Manifestations (Neurological Manifestations)
08/2013
1Gliosis
02/2013
1Vitamin D Deficiency
09/2012
1Necrosis
09/2010
1Premature Obstetric Labor (Premature Labor)
10/2008
1Fetal Death
10/2008
1Adrenoleukodystrophy (Adrenoleukodystrophy, X-Linked)
07/2006

Drug/Important Bio-Agent (IBA)

8Lovastatin (Mevacor)FDA LinkGeneric
09/2013 - 10/2004
5Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA
11/2010 - 10/2004
3CytokinesIBA
09/2013 - 04/2006
3Peroxisome Proliferator-Activated Receptors (PPAR)IBA
09/2013 - 11/2010
2Metformin (Glucophage)FDA LinkGeneric
08/2013 - 06/2013
2AMP-Activated Protein KinasesIBA
08/2013 - 09/2006
2AntioxidantsIBA
02/2011 - 10/2008
2RolipramIBA
01/2009 - 12/2008
2PPAR alphaIBA
05/2008 - 04/2008
1rho GTP-Binding Proteins (rho GTP-Binding Protein)IBA
09/2013
1Neurofilament ProteinsIBA
06/2013
1Pharmaceutical PreparationsIBA
06/2013
1CholesterolIBA
06/2013
1Ciliary Neurotrophic Factor (CNTF)IBA
02/2013
1Cholecalciferol (Vitamin D3)FDA Link
09/2012
1Calcitriol (Calcijex)FDA LinkGeneric
09/2012
1Interleukin-17 (Interleukin 17)IBA
02/2011
1Interleukin-6 (Interleukin 6)IBA
09/2010
1Drug CombinationsIBA
01/2009
1Oxidoreductases (Dehydrogenase)IBA
12/2008
1LipopolysaccharidesIBA
10/2008
1Cysteine (L-Cysteine)FDA Link
10/2008
1Phospholipids (Phosphatides)FDA LinkGeneric
10/2008
1long-chain-fatty-acid-CoA ligaseIBA
07/2006
1Fatty Acids (Saturated Fatty Acids)IBA
07/2006
1Interleukin-4 (Interleukin 4)IBA
04/2006
1NF-kappa B (NF-kB)IBA
04/2006
1PPAR gammaIBA
04/2006
1LipidsIBA
09/2005

Therapy/Procedure

5Therapeutics
02/2011 - 09/2006
1Induced Abortion (Induced Abortions)
10/2008